Combine art galleries with modern architectural lofts and welcome to Soho. From Canal to Houston Streets and Lafayette to Varick Streets, wander through the historic cobblestoned streets and past cast-iron buildings. As one of the trendiest and most expensive neighborhoods in Manhattan, SoHo not only takes the cake but eats it too when it comes to fashion, from bargain-hunters to luxury, it’s the epicenter of style. Don’t expect to find traditional Manhattan numbered streets here, SoHo does stand for South Houston Street afterall.